The structure and function of centriolar rootlets
网页2021年8月18日 · A major evolutionary conserved constituent of rootlets in the Animalia kingdom is rootletin protein (also known as ciliary rootlet coiled-coil protein, which in humans is encoded by the CROCC gene) (Yang et al., 2002).
Rootletin organizes the ciliary rootlet to achieve neuron sensory ...
网页2015年10月10日 · In many cell types, a fibrous cytoskeletal structure called the ciliary rootlet links the base of the cilium to the cell body. Across species, the rootlet ultrastructure consists of cross-striations appearing at intervals of …
The Ciliary Rootlet Maintains Long-Term Stability of Sensory Cilia
网页The striated ciliary rootlet is a prominent cytoskeleton originating from basal bodies of ciliated cells. Although a familiar structure in cell biology, its function has remained unresolved. In this study, we carried out targeted disruption in mice of the gene for rootletin, a component of the rootlet.
Microridge-like structures anchor motile cilia
网页2022年4月19日 · We analyzed the rootlet position of single cilia by transmission electron microscopy (Fig. 2A), and generated 3D reconstructions (Fig. 2B) to determine the distance between the tip of rootlets...
The ciliary rootlet interacts with kinesin light chains and may …
网页2005年10月1日 · The ciliary rootlet is a large striated fibrous network originating from basal bodies in ciliated cells. To explore its postulated role in intracellular transport, we investigated the interaction between kinesin light chains (KLCs) and rootletin, the structural component of ciliary rootlets.
A cryo-ET study of ciliary rootlet organization - bioRxiv
网页2023年9月5日 · In this study, we obtain 3D reconstructions of membrane-associated and purified rootlets using cryo-electron tomography (cryo-ET). We show that flexible protrusions on the rootlet surface, which emanate from the …
Rootletin, a novel coiled-coil protein, is a structural component …
网页2002年11月11日 · The ciliary rootlet, first recognized over a century ago, is a prominent structure originating from the basal body at the proximal end of a cilium. Despite being the largest cytoskeleton, its structural composition has remained unknown. Here, we report a novel 220-kD protein, designated rootletin, found in the rootlets of ciliated cells.
网页In many cell types, a fibrous cytoskeletal structure called the ciliary rootlet links the base of the cilium to the cell body. Across species, the rootlet ultrastructure consists of cross-stria-tions appearing at intervals of 50–70 nm along its length (Faw-cett and Porter, 1954).
Striated Rootlet and Nonfilamentous Forms of Rootletin Maintain Ciliary …
网页2013年10月21日 · In vivo analyses reveal that CHE-10/rootletin maintains ciliary integrity partly by modulating the assembly, motility, and flux of IFT particles, which are critical for axoneme length control. Surprisingly, CHE-10/rootletin is also essential for stabilizing ciliary transition zones and basal bodies, roles not ascribed to IFT.
A cryo-ET study of ciliary rootlet organization - eLife
网页2024年9月2日 · In this study, we obtain 3D reconstructions of membrane-associated and purified rootlets using cryo-electron tomography (cryo-ET). We show that flexible protrusions on the rootlet surface, which emanate from the …
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