The San Francisco 49ers can breathe a sigh of relief following the latest update on Isaac Guerendo’s injury status. However, ...

Rookie Isaac Guerendo battled injuries himself after taking the lead role in the backfield, and was carted off during the ...

San Francisco 49ers running back Isaac Guerendo was carted off the field in the first quarter against the Arizona Cardinals.

The 49ers lost their standout rookie Isaac Guerendo in scary fashion. What update did the running back provide Monday?

San Francisco running back Isaac Guerendo was injured and carted off early during the 49ers' season finale versus the Arizona ...

Rookie running back Isaac Guerendo was carted off the field less than two minutes into the first quarter during the 49ers’ ...

Coach Kyle Shanahan said after Sunday's 47-24 loss to the Cardinals that Guerendo (knee/ankle) likely suffered an MCL sprain and will undergo further testing Monday, Lindsey Pallares of the 49ers' ...

San Francisco provided an initial injury update on RB Isaac Guerendo following the 49ers’ season finale vs. Arizona.

The season from the abyss is finally over for the San Francisco 49ers. They suffered a blowout loss to the Arizona Cardinals, ...

The San Francisco 49ers have had to deal with multiple running back injuries this season and another went down in Week 18 against the Arizona Cardinals. Rookie Isaac Guerendo went down on the fourth ...

The 49ers have running backs Christian McCaffrey (knee), Elijah Mitchell (hamstring) and Jordan Mason (ankle) on injured reserve, which elevated Guerendo to the starting role Dec. 8. They have started ...

Should I start or sit Isaac Guerendo for fantasy football in Week 17? Read our fantasy football start 'em, sit 'em picks and ...