Pharmacokinetics is an area of pharmacology concerned with the time course of absorption, distribution, metabolism and excretion (collectively ADME) of drugs from biological systems in order to ...

Direct Oral Anticoagulants (DOACs) have significantly improved anticoagulation therapy – due to their ease of use, predictable pharmacokinetics, and a reduced risk of certain adverse effects compared ...

Aging is associated with the progressive impairment of multi-organ function, which can impact the pharmacokinetics of antimicrobials, potentially leading to the failure of anti-infective therapy. With ...

A committee member pointed out that, although the design of the trial was appropriate when it was started, ximelagatran should be compared with warfarin in view of the current data on the efficacy ...

Pharmacogenomics has played a key role in the safety and efficacy of drugs such as warfarin and Herceptin ®. Genetic consideration throughout the drug-development process would greatly improve ...