Mr MO Fitzpatrick, Department of Neurosurgery, Institute of Neurological Sciences, Southern General Hospital NHS Trust, Glasgow, UK. If you wish to reuse any or all ...

Background Sporadic inclusion body myositis (sIBM) is an intractable muscle disease that frequently affects elderly people. Autoantibodies recognising cytosolic 5’-nucleotidase 1A (cN1A) were found in ...

Introduction Sex differences in dementia with Lewy bodies (DLB) have been reported in clinically defined cohorts; however, clinical diagnostic accuracy in DLB is suboptimal and phenotypic differences ...

Some patients ultimately diagnosed with primary CNS lymphoma (PCNSL) have transient symptomatic contrast enhancing lesions. These "sentinel lesions" of PCNSL recede spontaneously or with ...

Department of Clinical Neurophysiology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK Correspondence to: Dr Arup Mallik Department of Clinical Neurophysiology, Institute ...

Correspondence to Dr Romain Bourcier, Department of Diagnostic and Therapeutic Neuroradiology, University Hospital of Nantes, L’institut du thorax, Inserm 1087, CNRS, UNIV Nantes, University Hospital ...

Correspondence to Dr M Braschinsky, Department of Neurology, University of Tartu, Puusepa 2, Tartu 51014, Estonia; mark.braschinsky{at}kliinikum.ee Background Hereditary spastic paraplegia (HSP) ...

Adult-onset leukodystrophies and genetic leukoencephalopathies comprise a diverse group of neurodegenerative disorders of white matter with a wide age of onset and phenotypic spectrum. Patients with ...

University of Iowa, The Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA Objective: The objective of the Predict-HD study is to use genetic, neurobiological and refined clinical ...

Background Cell-derived exosomes have been demonstrated to be efficient carriers of small RNAs into brain tissue. However, the therapeutic effect of exosome-mediated siRNA has not been tested in ...

In 2021, the National Institute for Health and Care Excellence produced an evidence-based guideline on the diagnosis and management of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a ...

Background: Cerebral small vessel disease is a common cause of cognitive impairment and vascular dementia. The cognitive deficit differs from that in Alzheimer’s disease, with greater ...