People of Ashkenazi Jewish descent are at higher risk of developing pancreatic cancer because they are more likely than other ...

Breast cancer is the second most common cancer among American women. Breast cancer death rates have been falling over the past 30 years. But nearly 13% of women are still diagnosed in their lifetime.

乳腺癌到底会不会遗传？这个问题困扰着无数女性及其家庭。乳腺癌是全球女性中最常见的恶性肿瘤之一，每年有成千上万的女性被诊断出患有这种疾病。随着医学研究的不断深入，人们越来越关注乳腺癌的遗传性问题，但遗传性的不确定性也引发了广泛关注。 遗传因素在乳腺癌中扮演着重要角色。BRCA1和BRCA2基因突变是最为人们熟知的遗传风险因素。携带这些基因突变的女性患乳腺癌的风险显著增加。研究表明，BRCA1突变携带 ...

引言DNA双链断裂（DSB）是细胞分裂过程中最严重的DNA损伤类型之一，如果不及时修复，会导致基因突变和癌症。同源重组（HR）是DSB修复的主要途径之一，HR依赖于同源染色体之间的序列匹配，以修复DSB【1】。HR的启动需要先对DSB末端进行DNA端 ...

Dr Lisa Dalmeyer unpacks the significance of the BRCA gene, early detection strategies and the implications for families ...

乳腺癌作为女性癌症相关死亡的主要原因之一，目前已有多种药物靶向性生物标志物和预测性生物标志物被开发出来。下一代测序（NGS）技术在乳腺癌的精准诊疗领域扮演着至关重要的角色，并已成为针对TP53、PIK3CA、ESR1、BRCA1/2等常见突变基因检测 ...

Understanding genetic risks and identifying BRCA1 and BRCA2 mutations can guide preventive and personalised treatment strategies for patients at high risk of hereditary breast cancer.

例如，在遗传方面，BRCA1和BRCA2基因突变是最广为人知的遗传性乳腺癌相关基因，携带者终生患乳腺癌的风险可高达80%，对有家族史的高危人群可以进行基因检测；早初潮、晚绝经、未生育或晚育都可能增加乳腺癌发病风险，长期使用雌激素替代疗法也可能增加患 ...

The past decade has witnessed a rapid expansion of genetic tests, including new instruments to inform patients who have been ...

Hormonal contraceptive use in BRCA1 mutation carriers was associated with increased risk of BC, with users having a proportional increase in risk of 3% for each year of hormonal contraceptive use. No ...

你好千金“你好千金——女生健康中国行”是中国妇女杂志社携手千金药业推出的科普公益项目，旨在走进校园和社群，为女学生和中青年女性开展妇科健康讲座和咨询服务。项目采用线上+线下相结合方式，自2016年发起至今，已累计邀请1200多位知名健康专家，走进全国 ...