Hi-C技术源于染色体构象捕获（Chromosome Conformation Capture—3C）技术，以整个细胞核为研究对象，利用高通量测序技术，结合生物信息学方法，研究全基因组范围内整个染色质DNA在空间位置上的关系，揭示染色体的三维结构。2015年，美国国立卫生研究院（NIH ...

2009). Hi-C is a 3C derivative, based on proximity ligation of cross-linked DNA with a biotin linker, which is used to pull down the fragments, followed by high-throughput sequencing. From eight ...

近几年，染色体三维结构作为崭新的研究方向，在疾病研究中的地位越来越重要，高分文章层出不穷。本月18号，来自英国Babraham研究所的科学家利用捕获Hi-C技术，发现了成千上万与特定疾病相关的新基因，包括类风湿性关节炎、1型糖尿病和Crohn氏病。小编先带 ...

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