Primary and review articles published in English were identified by a MEDLINE (1966-June 2003) search using the MeSH terms "hot flashes," "hot flushes," "menopause," and "serotonin reuptake inhibitor.

Although the results of these studies demonstrate that venlafaxine, fluoxetine, and paroxetine reduce hot flashes, significant limitations exist. The total number of unique patients considered ...