The mean reduction in hot flash score in the combined placebo arms of all studies was 24%. The antidepressants paroxetine (10–25 mg per day), fluoxetine (20 mg per day), sertraline (50–100 mg ...

Women taking other agents for hot flashes, hormonal therapy other than tamoxifen, or antidepressants were excluded. The primary endpoints, hot flash frequency and severity, were documented in ...

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“As the definitive physiology of hot flashes is not known, I believe it cannot be assumed that the efficacy of the new antidepressants for hot flashes is a class effect,” says lead researcher ...